Guatemala is an active participant in the GEF-8 Sustainable Cities Integrated Program (SCIP), with the Guatemala City Metropolitan Area and secondary cities such as Huehuetenango advancing integrated, climate-responsive urban development. As one of Central America’s most ecologically diverse countries, Guatemala faces pressing urban challenges—from rapid expansion and informal growth to rising climate risks, water stress, and environmental degradation. Through SCIP and the GPSC Global Knowledge Platform, Guatemalan cities are strengthening metropolitan governance, enhancing land-use planning, and expanding nature-based solutions to improve resilience. The program also supports the creation of a Sustainable Cities Coalition, fostering coordination across municipalities and national agencies. Guatemala’s engagement offers valuable lessons for the global GEF network, particularly on integrating biodiversity, territorial planning, and climate adaptation in rapidly growing urban regions.