Saint-Louis, located at the mouth of the Senegal River, is a UNESCO World Heritage Site and one of West Africa’s most climate-vulnerable coastal cities. Participating in the GEF-6 Global Platform for Sustainable Cities (GPSC), Saint-Louis is integrating climate risks into urban planning and infrastructure design. The project enhances capacity for city management, promotes climate-resilient housing and public infrastructure, and strengthens national urban policy frameworks. Through the preparation of a Sustainable Cities Master Plan, Saint-Louis develops a strategic vision and pilot investments to address sea level rise, flooding, and coastal erosion. These interventions aim to safeguard the city’s cultural heritage, protect livelihoods, and promote sustainable, adaptive urban development along Senegal’s coastline.