Chile plays an active role in the GEF-8 Sustainable Cities Integrated Program (SCIP), with several cities—including Santiago Metropolitan Area, Antofagasta, Valdivia, and Coyhaique—advancing integrated, climate-smart urban development. As a country with extraordinary geographic and ecological diversity, from desert landscapes to temperate rainforests, Chile faces growing urban challenges linked to climate change, water scarcity, air pollution, and land-use pressures. Through SCIP and the GPSC Global Knowledge Platform, Chilean cities are strengthening nature-based solutions, green infrastructure, circular economy models, and decarbonization strategies, while improving data-driven planning and resilience across metropolitan regions. Chile’s leadership in environmental policy, renewable energy, and urban innovation continues to provide valuable lessons to the global GEF city network, demonstrating how cities can transition toward more livable, low-carbon, and nature-positive futures.